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NAD+/NADH ratio assays, SIRT1 activity assays, and mitochondrial respiration measurements (such as oxygen consumption rate via extracellular flux analysis) are standard methods for studying this combination's proposed effects in cell-based models, typically comparing single-compound and combined-compound treatment conditions against untreated controls

Not on the DEA controlled substance list Not scheduled, but falls into a gray zone under FDA enforcement WADA (World Anti-Doping Agency): Tesofensine is not currently listed on the WADA Prohibited List , but athletes in drug-tested sports should use extreme caution

USA 95 , 59875992 (1998)

Any excess is typically excreted in the urine, lowering the risk of toxicity