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The bottom line NAC is one of the most clinically validated supplements available, with a 60+ year pharmaceutical history as both an acetaminophen antidote and a mucolytic agent

While a 2014 pooled analysis of seven RCTs concluded neither benefits nor harms of the supplementation in patients with heart failure [126], the 1993 and 2020 RCTs supported the supplementations benefit on improved endothelial function, reduced hospitalization, and reduced serious complications in patients with heart failure [127,128]

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