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Berberine should be avoided during pregnancy and breastfeeding due to potential risks to the infant, including concerns about effects on bilirubin metabolism in newborns

"L-carnitine and weight loss: meta-analysis." Obes Rev 2016;17:970-6
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Moreover, exogenously administered -hydroxybutyrate is not anticonvulsant in animal models such as the Frings audiogenic seizure-susceptible mouse [17]
