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For the targeting of skin, nanotechnology has opened new opportunities for topical drug delivery

Problems in the hypocretin system can be a precursor to emotional disorders such as narcolepsy and depression

doi: 10.1016/j.jconrel.2024.07.010 44 ChenY.YangX.LiJ.LuoH.HuangQ.YangW.et al

His159 serves as proton acceptor, which interacts directly with nitrogen of the peptide bond to be cleaved
