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You should contact your GP or healthcare professional if you experience: Heavy bleeding (soaking through a pad or tampon every hour for several consecutive hours) or passing large clots Prolonged bleeding lasting more than seven days or bleeding that does not stop Severe pelvic or abdominal pain that is new, persistent, or worsening Postmenopausal bleeding (any vaginal bleeding occurring 12 months or more after your last period) this requires an urgent 2-week suspected cancer referral [11] Bleeding between periods that is recurrent, increasing in frequency, or accompanied by other concerning symptoms Signs of anaemia , such as extreme fatigue, dizziness, shortness of breath, or pale skin It is also important to seek advice if you have missed periods and there is any possibility of pregnancy

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Focal adhesion kinase (FAK) and paxillin are proteins that anchor cells and signal migration and adhesion