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In this article, we presented two chromatographic techniques that can be employed for simultaneous determination of the current analytes, with the aim of achieving cost-effectiveness, time efficiency, green, applicability and improved suitability for routine analysis

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Glutamate may also induce intra-articular inflammatory responses and abnormal pain in OA patients by activating N-methyl-D-aspartic acid (NMDA) receptors, further advancing OA progression (Piepoli et al., 2009)

671 Multidisciplinary management A multidisciplinary approach involving endocrinologists, neurologists, podiatrists, pain specialists, and rehabilitation therapists is crucial for the comprehensive management of DN patients