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At very high concentrations of hydroperoxide the selenium centre in GPx may be overoxidized to produce seleninic acid (ESeO 2 H) and selenonic acid (ESeO 3 H)
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developed a pH-responsive charge-reversal polyelectrolyte, and an integrin V3 antibody-functionalized GO complex was developed for targeted, controlled release of DOX, enabling selective drug release in acidic intracellular organelles for enhanced cancer treatment [78]
