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For example, the ionizable lipid material DAL4-LNP containing diaminic groups of different head groups (DAL) can efficiently deliver different mRNAs to tumor cells, and intratumoral injection of DAL-LNPs loaded with IL-12 and IL-27 mRNA can induce CD8 + T cell infiltration into tumors and significantly inhibit tumor growth compared to IL-27 and GM-CSF mRNA monotherapy (145)

doi: 10.1186/s12864-021-07480-x

doi: 10.1093/ajcn/87.5.1128

As such, the split-dose L-carnitine protocol may offer a practical supplementation strategy for a broader athletic population seeking to optimize endurance capacity under high training loads