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Concomitant GSK-3 and E-cadherin inhibition with cytosolic -catenin accumulation leads to NF-B-dependent iNOS expression in hepatic cells [91]

Today 19 , 17311743 (2014)

Thus, directly inhibiting the signalling molecule GSK3, which mimics activation of the Wnt pathway, was used to induce the differentiation of hPSCs to definitive endoderm and then to the hepatic lineage 11,12,13

Emerging evidence demonstrates that hypomagnesemia or intracellular magnesium deficiency is strongly associated with the development and progression of various liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcoholic liver disease (ALD), drug-induced liver injury (DILI), and hepatocellular carcinoma (HCC)