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doi: 10.3389/fphar.2020.580289
Localized nanodelivery platforms can improve sitespecific targeting and reduce systemic exposure, yet their longterm safety, pharmacokinetics, release profiles and therapeutic durability require rigorous validation in relevant largeanimal models and clinical trials
In addition, melatonin can modulate redox signaling pathways, such as Nrf2, and regulate the gene expression of antioxidant enzymes such as SOD, GPx, and CAT [26]
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