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ImmTOR inhibits the development of uricase-specific ADAs in a dose-dependent manner, thus enabling sustained enzyme activity and reduction in serum uric acid levels

Metformin was selected as first-line treatment because of its record of safety and efficacy, as well as its low cost (Gold Standard 2015c)

The reaction of the phenylazopyridine ligand and the iodo ruthenium arene precursor yielded the desired ruthenium catalyst Ru(II)-OH (synthetic strategy: Supplementary Fig
