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This was evidenced by the increased presence of macrophages and CD8 + T cells, along with elevated mRNA expression levels of IL-2, IL-12, IL-10, TNF-, IFN-, and programmed death ligand-1 (PD-L1) in the site of the tumor

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(2) Hcy may negatively affect glutathione peroxidase activity and thus transcription of glutathione
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Novo Nordisk filed for FDA approval of CagriSema in early 2026, with a review decision expected later this year
