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Preclinical studies in rodents have demonstrated reductions in fat mass, improved insulin sensitivity, and increased metabolic rate without significant changes to food intake (Neelakantan et al., 2019)
Isatuximab (SAR650984) and Daratumumab are instead monoclonal antibodies that target CD38, which is also highly expressed on multiple myeloma (MM) cells
In clinical studies, it has been shown to have beneficial effects on skin aging, muscular homeostasis, diabetes, Alzheimer disease, cardiovascular disease, and osteoporosis
