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Covariates were the baseline values to adjust for initial differences (for CGI-I, day 7 was used as covariate)
The accumulation of amyloid plaques is a pivotal factor associated with subsequent neuronal toxicity in AD pathogenesis, eventually leading to destruction of synaptic structures and severe cognitive deficits (Zhu et al., 2024)
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It is not the only possible explanation, as plateaus happen , but storage should be one of the first things you investigate
