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In older adults with mild cognitive impairment, 16 weeks of 3 g/day supplementation produced measurable cognitive improvements, though benefits did not persist after discontinuation

A 2019 case report describes a case of a young woman who was treated for severe pernicious anemia with multiple daily doses of 1 milligram (mg) of cyanocobalamin, a synthetic form of B12

4.1.5 Cullin-3 (Cul3) In Drosophila , Cul3, a member of the Cullin E3 ligase family, plays a significant role in circadian regulation (Guo et al., 2014)

Though uncommon, vitamin B12 may sting a little on injection, though this is usually a short-lived side effect