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The idea that MOR internalization negatively influences the development of tolerance is also supported by experiments carried out in wild type animals where the rate at which analgesic efficacy diminishes is faster for low internalizing opiates like morphine or heroin [38, 7779] than for efficiently internalizing agonists like DAMGO [80], etorphine [38, 81] or methadone [38, 77]

[DOI] [PubMed] [Google Scholar] 105.Malberg J.E., Eisch A.J., Nestler E.J., Duman R.S

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