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Description
This neurotrophin supports the survival of existing neurons, encourages the growth of new neurons and synapses, and underlies the brains capacity for learning and memory
The failure of achieving a survival advantage along with serious tolerability issues created controversy over the real value of bevacizumab treatment in metastatic breast cancer and further brought its approval into question
Thus, current knowledge is largely hypothesis-generating and highlights the urgent need for well-designed clinical and translational studies
Yang et al., 2017a
