glutathione mat2a Design and Structural Optimization of Methionine Adenosyltransferase 2A ( MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability AG-270 | MAT2A Inhibitor |
Description
Just as low intracellular GSH levels decrease cellular antioxidant capacity, elevated GSH levels generally increase antioxidant capacity and resistance to oxidative stress, and this is observed in many cancer cells
Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma
10.1016/j.tcb.2020.02.009 141 StoyanovskyD
doi: 10.1371/journal.pbio.0060184 39 JiDXYamashiroLHChenKJMukaidaNKramnikIDarwinKHet al
