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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Shi KQ, Tang JZ, Zhu XL, et al

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Under the stimulation of high mechanical stress, activation of the PIEZO1 protein leads to a decrease in the intracellular GSH level of chondrocytes, a reduction in the function and expression of GPX4, and a significant increase in the intracellular calcium ion concentration, ultimately inducing ferroptosis of chondrocytes