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Measurement of mitochondrial permeability transition pore (mPTP) opening and ATP level The cerebral cortex and hippocampus of the infarct penumbra of the rats (n = 10) were isolated 24 h after MCAO

Additionally, we investigated the neuroprotective mechanism of meldonium against CIRI

Oxidative stress can result in vascular endothelial cell injury (83, 230234), neuronal cell compromise (66, 122, 123, 152, 156, 162, 233, 235245), alterations in neurotransmitters (69, 246, 247), myelin degradation (79, 224, 248252), cell senescence (55, 112, 253255), loss of stem cell proliferation (66, 168, 228, 241, 251, 256259), and cognitive impairment (120, 121, 200, 223, 243, 245, 260266)