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Ferroptosis can be triggered once the balance between the generation and the clearance of lipid peroxidation is disrupted, such as the inhibition of GPX4 and the depletion of GSH 25

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10.1016/j.tifs.2021.01.030 [DOI] [Google Scholar] 4.Tang GY, Meng X, Gan RY, Zhao CN, Liu Q, Feng YB, et al

To address this issue, the combination of immunotherapy with other drugs, for example, the combination of the commonly used PD-1/PD-L1 inhibitors and mature natural plant products, including luteolin, baicalin and -Elemene (Lee J
