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Description
This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity
The peptides seven amino acid sequence LKKTET shows activity at approximately 50 nanomolar concentration
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They are vitamin B12, choline, methione, and inositol
