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On this basis, the presence of microvascular alterations in a pre-diabetic mouse model also suggests that early hyperinsulinaemia and insulin resistance are sufficient to induce vascular damage and that bloodbrain barrier dysfunction precedes cognitive decline (25)

J.GoudriaanA.Blits-HuizingaC.BolJ

[DOI] [PubMed] [Google Scholar] 2.Wessjohann LA, Schneider A, Abbas M, Brandt W

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