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NRF2, Nuclear factor erythroid 2-related factor 2 Background NADPH, the reduced form of nicotinamide adenine dinucleotide phosphate (NADP + ), is an essential co-factor for enzymes that catalyze a wide variety of oxidative and antioxidative processes [1]

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(b) The oxidation of the PrSH yields a thiyl radical (RS ), which reacts with the deprotonated form of glutathione (GS ), forming a mixed disulfide radical (RSSG )

Coenzyme Q10 and nicotinamide nucleotide transhydrogenase: Sentinels for mitochondrial hydrogen peroxide signaling