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Clin Pharmacol Ther 2001 Dec

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Restless legs syndrome (RLS) management typically involves lifestyle measures such as reducing caffeine and alcohol consumption, stopping smoking (if relevant), and undertaking moderate regular exercise 4 5

2019 Cochrane Review: A Cochrane review of RCTs on ALCAR for diabetic peripheral neuropathy concluded very low-certainty evidence (GRADE system) indicating uncertainty regarding short-term pain relief, but noted potential improvements in nerve conduction velocity