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In animal models, there was also found degeneration of the SL, which correlates with SV degeneration, in the cochlea of quiet-aged gerbil [65]

Therefore, structurally modified analogues with an altered OXM pharmacological profile have been produced with longer duration of action, good safety profile, and positive effects on body weight (and glucose metabolism) management in animal studies (143)

However, despite a higher EC50 concentration, at equimolar concentrations in the higher ranges maximal IGF-IR stimulatory activity achieved by full-length MGF was similar (90-fold) to that after recombinant human IGF-I (82-fold)

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