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Furthermore, GSTs are additionally identified as regulators of cellular signaling pathways, thereby influencing cell proliferation or apoptosis ( in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds

Hence, the ratio between the concentration of 5-HETE and leukotriene B 4 (LTB 4 ) will increase if GPX4 is activated

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Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: From cofactors to antioxidants to redox signaling