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Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results

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Tumor cells overexpressing HER2 show marked increases in lactate dehydrogenase-A (LDHA) resulting in high intra-tumor lactate production to sustain glycolysis and cancer cell growth [45, 46]

The uneven distribution of ascorbate is due to the fact that SVCT2 is preferentially expressed in neurons