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It is commonly studied in models involving soft tissue repair, gastrointestinal barrier integrity, inflammatory signaling, vascular response, and connective tissue remodeling
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AMPK inhibits mTOR, and downregulation of mTOR has been shown to promote lifespan in several organisms and thus regulation of mTOR by AMPK provides another likely mechanism by which AMPK could influence lifespan (Jia et al., 2004
