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The importance of ECM cleavage in this process is evident from the phenotype of mice lacking metalloproteinases: a lack of MMP11 leads to a decreased periductal collagen content and decreased mammary gland morphogenesis 63

Gu S, Liu F, Xie X, Ding M, Wang Z, Xing X, Xiao T, Sun X (2023) -Sitosterol blocks the LEF-1-mediated Wnt/-catenin pathway to inhibit proliferation of human colon cancer cells

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Ultimately, integrating allergology and gastroenterology insightsas this review has attemptedcan generate novel hypotheses and therapies