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Littman, Susan

Much of the research done to examine links between antidepressant drugs and mitochondrial function have used the SSRI fluoxetine, which may either inhibit or trigger mitochondrial apoptosis and alter activity of the ETC, depending on the cell type ( in vitro inhibited state 3 of mitochondrial respiration for -ketoglutarate and succinate oxidation, stimulated state 4 for succinate, and decreased the respiratory control ratio for both oxidizable substrates ( In vivo studies reveal a slightly more complex scenario, in that fluoxetine has both beneficial and detrimental effects on mitochondria when given systemically

K.RajpootR.RaniA.PandeyA
613 In a phase 2 study, vixotrigine was investigated for the treatment of idiopathic or diabetes-associated painful SFN
