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Immunolocalization studies with specific GSH-fluorescent labeling revealed that under control conditions GSH is present in all cellular compartments of root and leaf cells, with the exception of the apoplast [158,159]
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Consequently, attenuated xCT expression at both transcriptional and protein levels (with concomitant GPX4 reduction) intensified ferroptosis, amplifying renal tubular epithelial cell injury
