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PINK1, as a mitochondrial damage sensor, is activated by mild oxidative stress and further triggers mitophagy to remove ROS and prevent cellular damage [167]

E2F activates the transcription of pro-S phase cell cycle genes, promoting G1/S phase transition ( In families without mutations in CDKN2A and CDK4 genes, the use of NGS methodologies has allowed the identification of rare germline mutations in a few novel melanoma susceptibility genes, namely BRCA1 Associated Protein 1 (BAP1), TERT , Protection of Telomeres 1 ( POT1 ), ACD Shelterin Complex Subunit and Telomerase Recruitment Factor ( ACD ), TERF2 Interacting Protein ( TERF2IP ) (high risk genes) and MC1R, MITF (low to moderate risk genes)

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Hair repigmentation associated with thalidomide use for the treatment of multiple myeloma