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While so far only selected ABC transporters, including ABCB1 and ABCG2, have been studied for their role in BCL-2 inhibitor transport 66,67 , we investigated all 48 ABC transporters using an unbiased CRISPR/Cas9 screening approach in AML

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cerevisiae , provided the formation of an excess of glycine from the exogenous threonine following its supplementation to the growth medium to 50 mM, and improved riboflavin biosynthesis by eightfold (Table 3