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In addition to decreasing GSH, OTA inhibition of Nrf2 expression will decrease the production of the GST isoform GSTP1, which facilitates the detoxification of the lipid peroxidation product 4-hydoxynonenal (4-HNE) by facilitating the conjugation of 4-HNE with GSH

In the present study, it was planned to determine whether administration of NAC would increase reduced glutathione in the aqueous of patients with RP and samples were collected and stored for that purpose

232 Overall, this upregulation of BDNF by Wnt/-catenin signaling contributes to nerve repair during an ischemic stroke by promoting neurogenesis and neuronal survival

Kramer, A