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Overproduction of reactive oxygen species further exacerbates oxidative stress, enabling viruses to infiltrate the brain and contributing to cognitive difficulties such as memory loss, poor concentration, and reduced mental clarity ( FIGURE 3 )

The donor substrate is surrounded by an extended amino acid network, characterized by a H-bonded interaction involving the side chains of Tyr126 with the C 4 carbonyl of the uridine moiety, which is trapped by a pi-Sigma interaction with Arg61 and a pi-Alkyl interaction with Val143, in a hydrophobic cavity also shaped by residues Leu59, Asp91, Arg139

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