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Most of the clinical research has been conducted in rodent models, but the biological similarities between rodents and humans present a promising picture of how MOTS-c might impart systemic health benefits

While RsrR harnesses the same IscR-like 2Fe2S cluster as a sensory module for redox sensing (Figure 17B), 509 RirA 512 and NsrR 513 utilize a 4Fe4S cluster to detect iron limitation and nitric oxide, respectively (Figure 17C)

MetalPDB in 2018: A Database of Metal Sites in Biological Macromolecular Structures

This combination is widely studied in laboratory settings for synergistic effects on tissue repair, recovery, and regenerative pathways