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Our findings revealed that in osteosarcoma cells with downregulated SLC38A5, there was a reduction in both glutamine uptake and GSH levels

This approach is exemplified by Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase that diverts pyruvate away from lactate conversion and into mitochondria, and by Lonidamine, which suppresses glycolysis at its origin by inhibiting mitochondrially-bound hexokinase

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The latter are converted to monosaccharides by intestinal saccharidases, including maltase that hydrolyzes di- and trisaccharides composed of glucose, and the more specific disaccharidases, sucrase-isomaltase, lactase (-galactosidase), and trehalase