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For instance, zopolrestat (1 M) attenuated ischemia-reperfusion injury in isolated diabetic rat hearts by reducing sorbitol and fructose accumulation, preserving ATP, and restoring redox balance [148], while results from a separate study revealed that it also normalized lactate and glutamate production, corrected the elevated NADH/NAD + ratio, and shifted substrate utilization from fatty acid oxidation (FAO) toward glycolysis [149]

doi: 10.1097/00001648-199501000-00019

LipiFlow is an FDA-cleared electronic medical device that removes meibomian gland blockages and restores gland function

The most frequently recognized functional disorders are those that arise as a consequence of inherited biochemical defects and that cause distinctive neurohistologic changes