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Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity

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Thus, following oral administration of an exceedingly high dose of 150 mol sulforaphane to 10-week-old female SpragueDawley rats, the concentration of dithiocarbamates in the plasma of the animals increased rapidly reaching a peak ( C max ) of 60 M 1 h after dosing, with area under the concentration curve (AUC) of 491 h mol/L, elimination constant ( K el ) of 0.1 h 1 , and elimination half-life of 6.7 h [55]

Serum IGF-1 levels, which would confirm that the blend is successfully stimulating the GH axis as expected