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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

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D64.81 coding and complex CMS coverage criteria apply Port placement: Many adjuvant chemotherapy patients receive subcutaneous implantable venous access devices (ports) for repeated IV access

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