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PathakPXieCNicholsRGFerrellJMBoehmeSKrauszKWet al

Quantitative coupling between pentose cycle and oxidative burst Without performing modelling-based metabolic flux analysis, the general glucose metabolism mode can be indicated by average labelling enrichment (defined by the average number of 13 C-labelled carbons per molecule) in lower glycolytic compounds such as DHAP and lactate from 1,2- 13 C glucose tracing

Additionally, metabolic dysregulation of metal ions such as iron, copper, and manganese in the brain can catalyze Fenton reactions, generating reactive oxygen species that exacerbate OS and protein misfolding [31]

doi: 10.1249/MSS.0000000000003676