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Heterozygous carriers or minors with one copy of the thalassemia trait gene have no symptoms whereas a child/adult with homozygous thalassemia will present with the disease

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MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis PMID: 34470889 Nat Commun

A direct association between HHcy and IR is well demonstrated by Golbahar and colleagues using Sprague Dawley (SD) rats [71]
