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Malaguarnera ( Tnf, Il6, Il1b ) and downregulates pro-fibrotic genes ( Acta2, Col1a2, Tgfb1, Pdgfrb, Pdgf-b, Pdgf-c ), reducing -smooth muscle actin (-SMA) and platelet-derived growth factor receptor beta (PDGFR) protein levels ( The anti-inflammatory and anti-fibrotic properties of L-carnitine underscore its potential to halt MASLD progression to advanced stages

Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action CJC-1295 (No-DAC) acts by binding to GHRH receptors on pituitary somatotrophs, stimulating GH synthesis and release in response to natural hypothalamic signaling