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VEGFC binding to VEGFR3 induces receptor dimerization, autophosphorylation, and internalization and activates PI3K/AKT and MAPK/ERK signaling pathways important for lymphangiogenesis [81] (Figure 2a)

Isotretinoin treatment is extremely effective for patients whose acne did not respond to topical creams or other oral medications, providing patients with long-lasting clear skin in 4-6 months

3 , e00092 (2015)
