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doi: 10.1111/j.1740-8261.2002.tb01003.x

(2015) 309:L105675

A functional study of human inflammatory arthritis using photoacoustic imaging

In a mechanistic study with different types of tumour cell lines, the silencing of Grx1 activated the p53 signalling pathway, causing the cell cycle to stop in G1 causing senescence [188], which supported the idea that antioxidant systems, including Grx1, get upregulated in tumour cells as survival mechanism to counteract the high amount of ROS due to the changes in metabolism
