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Data are available in a public, open access Open Science Framework (OSF) repository This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made

Generally, NNMT overexpression decreases SAM and S-adenosyl-L-homocysteine (SAH) levels and alters SAM/SAH in vivo and in vitro in an obvious manner (96)

articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the -Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Case Study-3 : MC4R Melanocortin Receptor Agonists Melanocortin Receptors articles Design of a New Peptidomimetic Agonist for the Melanocortin

In the case of RIMAs like moclobemide there is no need for dietary restrictions