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10.1186/s13024-019-0333-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 77.Breijyeh Z, Karaman R

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Previous studies in keratinocytes indicated that adequate intracellular stores of GSH protect against peroxide-mediated loss of GPx-1 activity, as addition of GSH to cultures minimized enzymatic inactivation of GPx-1 by exposure to high concentrations of peroxides, whereas buthionine sulfoximine, an inhibitor of GSH biosynthesis, augmented sensitivity to peroxide-induced GPx-1 inactivation (373)

To diagnose hepatic steatosis, it is necessary to demonstrate fat accumulation in more than 5% of hepatocytes on histopathological examination, in the absence of significant alcohol consumption or other causes of liver injury or steatosis, or to detect more than 5.6% fat using proton magnetic resonance spectroscopy (H-MRS) [19]