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The remaining carbon atoms of the glutarimide ring interact with the amino acids Trp382, Trp388, Trp402, and Phe404 through van der Waals bonds 51
Subsequently, the fluorescence intensity was determined using an enzyme-linked immunosorbent assay (ELISA) analyzer (Tecan/Infinite E plex, Switzerland)
Compelling evidence has shown that oncogene-induced replication stress and dNTP exhaustion 30,31
For the Alt-R CRISPR-Cas9 system (Integrated DNA Technologies, IDT) system, crRNAs targeting human or mouse PHD2 (EGLN1) and GSTP1 were designed using the IDT design tool
