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For a non-international armed conflict to exist, there must be intense violence between a state and a nonstate group that is both armed and organized. As a general rule, the authorities of the laws of war can only be invoked when the situation of violence exceeds law enforcement capabilities

Published reviews describe a large preclinical literature with limited human data and unknown clinical safety

Rai SN, Tiwari N, Singh P et al (2021c) Therapeutic potential of vital transcription factors in Alzheimers and Parkinsons disease with particular emphasis on transcription factor EB mediated autophagy

However, these observations have not been confirmed in large-scale human trials